Alternatively, AICAR treatment markedly attenuated the L-arginine-induced elevation within the serum ranges of ALT and AST in WT SAP mice, while these phenomena had been significantly inhibited in Nrf2 KO mice (Figure 7E). Therefore, these results indicate that Nrf2 performs an important function in the protecting effects of AICAR towards L-arginine-induced PALI in mice. It […]
